If the player moves on, they can return to the hospital at any time. The achievement of a one-star rating allows players to progress to the next hospital, though they may continue building up their current hospital by completing additional objectives to increase the rating to two or three stars. Newly introduced elements include star ratings, hospital levels, and room prestige. Players can research new rooms and machine upgrades in the Research room. The completion of challenges and other tasks awards 'Kudosh', a currency that can be used to unlock new items that can be placed within rooms and corridors. Examples of objectives include: making the hospital attractive enough, and finding cures for certain diseases, though the general goal is curing as many patients as possible. Every game year, there is an awards ceremony in which the player is given performance-based rewards. Otherwise, the player's reputation (a performance rating that affects the chances of new patients coming) is tarnished.

Players are issued with a certain number of vaccines to inoculate patients, and there is a reward if all infected patients are immunised. On later levels, players can also experience epidemics, during which an infectious disease spreads throughout the hospital. From time to time, an influx of patients with a specific disease can occur. The process of diagnosing patients begins in a GP's Office before they are sent for further diagnosis in other rooms, and eventually treatment. Only janitors with the Ghost Capture skill can remove them. When patients die, they sometimes become ghosts, which disrupt the hospital by terrorising patients and staff. Two Point Hospital features unique, comical conditions such as 'Light-Headedness' (having a light bulb for a head), 'Pandemic' (having a pan on one's head), 'Mock Star' (patients are Freddie Mercury impersonators), and 'Animal Magnetism' (having animals stuck to the patient's body). The player can manage several hospitals, each with their own layout objectives. Tasks include building rooms and amenities that satisfy the needs (such as hunger and thirst) of patients and staff (such as toilets, staff rooms, reception desks, cafés, seating, and vending machines), expanding the hospital into new plots, the hiring and management of doctors, nurses, janitors, and assistants to maintain the hospital and dealing with a variety of comical illnesses. Players take on the role of a hospital administrator charged with constructing and maintaining a hospital. Two Point Hospital features a similar style of gameplay to that of Theme Hospital. At the bottom is the adviser, and the current objectives are displayed at the top-right. Visible are a GP's Office, a General Diagnosis room, a toilet, and patients queuing outside a ward. A successor titled Two Point Campus was released in 2022. The game received seven major updates as downloadable content after its release which added new regions and illnesses to cure, as well as four item packs. The game was received positively by critics, garnering acclaim for its style, humour and its faithfulness to Theme Hospital's aesthetics, but criticised for its repetitiveness and room design.

Within weeks of release, Two Point Hospital was the second most downloaded game in the sales charts for Europe, Middle East, Africa, and Australia. The game was designed and developed by some of the creators of Theme Hospital, including Mark Webley and Gary Carr. Since visiting real hospitals is often unpleasant, the emphasis on humour to lighten the mood was deemed important by the developers. A spiritual successor to Bullfrog Productions' 1997 game Theme Hospital, players are tasked with constructing and operating an empire of hospitals in the fictional Two Point County, with the goal of curing patients of fictitious, comical ailments.

A version for Amazon Luna was also made available in November 2020. Console versions for the Nintendo Switch, PlayStation 4, and Xbox One were released in February 2020. Two Point Hospital is a 2018 business simulation game developed by Two Point Studios and published by Sega for Linux, macOS, and Windows.

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